Table 2.
Baseline and 30- or 60-months follow-ups and autopsy results in BD-MRI participants
| Case/sex | Outcome BL/30/60 | UPDRS gait | UPDRS motor | MMSE | ADRDA | Autopsy (1)1 Macroscopic findings | Autopsy (2)2 BD pathology | Autopsy (3) AD pathology |
|---|---|---|---|---|---|---|---|---|
| 1F | BL/N/D | −/− | −/− | 28/− | 0/− | Acute basilar thrombosis, SA, RAS, R-renal infarction | Probable-definitive: W2-3, L3, V3 | None |
| 2M | BL/D | 2 | 27 | 29 | 0 | Pneumonia, AHF, SA, RAS, contracted kidney | Definitive: W3, L3, V3 | Low |
| 3F | BL/N/N | −/−/− | −/−/− | 25/−/0 | 1/− | |||
| 4F | BL/N/N | 0/−/− | 0/−/− | 29/−/− | 0/− | |||
| 5F | BL/D | 1 | 17 | 21 | 1 | No brain | ||
| 6F | BL/N/N | −/−/− | 8/−/− | 27/25/24 | 0/0 | |||
| 7M | BL/D | 0 | 7 | 26 | 0 | No brain | ||
| 8M | BL/D | 2 | 30 | 24 | 0 | Pneumonia, CS, SA, RAS, contracted kidney | Definitive: W4, L3, V3 | Low-intermediate |
| 9M | BL/N/N3 | 0/−/− | 2/−/− | 26/−/− | 0/− | Sepsis, peritonitis, CS, SA, RAS | Definitive: W4, L3, V3 | Intermediate-high4 |
| 10F | BL/N/D | 1/− | 7/− | 29/− | 0/− | AHF, lung edema, CS, SA, RAS | Definitive: W4, L3, V3 | Low-intermediate |
| 11F | BL/F/F | 0/0/1 | 2/5/8 | 27/27/28 | 0/0 | |||
| 12F | BL/F/F | 0/0/0 | 0/2/3 | 29/30/30 | 0/0 | |||
| 13F | BL/F/N | 0/1/− | 4/23/− | 25/27/− | 0/1 | |||
| 14M | BL/D | 0 | 3 | 29 | 0 | AHF, lung edema, SA, RAS, cystic kidney | Definitive: W3, L3, V3 | None |
BL, baseline; F, followed up/tested; N, not tested (home visit, telephone interview, or refusal), D, died.
1
SA, systemic atherosclerosis; RAS, renal arterio-arteriolosclerosis, AHF, acute heart failure, CS, coronary sclerosis.
2
W3, L3, V3, white matter rarefaction: stage 3, lacunar state: stage 3, and small/large vessel diseases: stage 3.
3
Died between the 60- and 90-months follow-ups.
4
Associated AGD Stage III and mild Lewy-body pathology.