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(A) Dose dependent inhibition of pNP-GlcNAc hydrolysis by intact B. subtilis cells in the presence of BI.fgba confirming that the target is a GlcNAcase. (B) Morphological changes to B. subtilis upon exposure to BI.fgba. Control cells (left) were grown in the presence of 1 % DMSO and show the typical rod shaped cells. Cells on the right were treated with 0.8 × MIC (48 μM) BI.fgba and exhibit an elongated phenotype.
