Table 2.

Multivariable Predictors of Time to Graft Loss During the First 6 Months After Transplant

Predictor	HR (95% CI)	p-value
Ischemic timea
Quartile 3	1.3 (1.1–1.6)	0.009
Quartile 4	1.3 (1.1–1.5)	0.01
Age at HTx (recipient)	N/Ab	0.02
Female sex	1.2 (1.0–1.4)	0.009
Donor age < 1 year	1.4 (1.1–1.8)	0.005
Diagnosis vs cardiomyopathy
Congenital	1.7 (1.4–2.1)	<0.001
Other	1.4 (1.0–1.8)	0.02
Type of support vs none
ECMO	3.3 (2.5–4.3)	<0.001
Ventilator	1.8 (1.5–2.2)	<0.001
Inotropes	1.1 (0.9–1.4)	0.45
Dialysis after listing	2.1 (1.4–3.1)	0.001
Creatinine clearance vs ≥ 40c
<40	1.9 (1.5–2.5)	<0.001
Not reported	1.5 (1.1–2.0)	0.01
Bilirubin at HTx (recipient)	N/Ab	0.08
Prior sternotomy
Yes	1.8 (1.2–2.7)	0.004
Not reported	1.7 (1.2–2.6)	0.006
Era vs 1987–1992
1993–1996	1 (0.8–1.3)	0.62
1997–2000	0.8 (0.6–1.1)	0.13
2001–2004	0.6 (0.4–0.9)	0.01
2005–2008	0.5 (0.4–0.7)	<0.001

CI, confidence interval; ECMO, extracorporeal membrane oxygenation; HR, hazard ratio; HTx, heart transplantation.

^aReference group = ischemic time less than the median; quartile 3, 3.52–4.30 hours; quartile 4, >4.30 hours.

^bNo hazard ratios are associated with these continuous variables because restricted cubic splines were used to model them.

^cCalculated as ml/min/1.73².