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. 2014 Oct 1;106(11):dju268. doi: 10.1093/jnci/dju268

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© The Author 2014. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — Frequency of intraprostatic T cell subsets in biopsy and radical prostatectomy (RP) sections from patients treated with sipuleucel-T and untreated patients. A) Quantitation of CD8+cytotoxic T cells, effector CD4+ FOXP3- T cells, regulatory CD4+ FOXP3+ T cells, and CD56+ natural killer cells was performed using digital image analysis. Cell frequencies in the RP sections were again quantified in three compartments: benign glands, tumor interface, and tumor center. B) The relative composition of the mean T subset frequencies within the RP is presented. Means ± 95% confidence intervals are shown with horizontal bars. * Denotes P under .05, analysis of variance (ANOVA) methods for repeated measures with post-hoc comparisons with the RP interface compartment. All ANOVA tests were two-sided. RP = radical prostatectomy.