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. 2014 Jul 3;210(12):2001–2008. doi: 10.1093/infdis/jiu358

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© The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

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Figure 2. — Global sequence diversity in pfap2mu (left) and pfubp1 (right) across genome sequences from 631 P. falciparum isolates mapped to the 3D7 reference genome [23]. Colored bars at any chromosome position (horizontal axis) denote a nonreference substitution at that residue in the relevant isolate (vertical axis). At top is the regional origin of isolates in the analysis, comprising 8 laboratory isolates (L), 367 isolates from West Africa, 88 from East Africa, 151 from SE Asia, and 17 from Oceania (Oc). Codon S160N/T of pfap2mu and codon 1528 of pfupb1 are highlighted by red arrows at the bottom of the figure. For pfubp1, the position of 2 carboxy-terminal introns is also marked. Previous annotation of this region of chromosome 1 as 2 distinct genes (PFA0215w and PFA0220w) is shown above the right-hand figure.