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. 2014 Oct 30;79(22):11199–11204. doi: 10.1021/jo502260x

Table 1. Optimization of Cross-Coupling with Potassium Alkenyltrifluoroborates.

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entry palladium source (loading) base solvent P:SPa
1 XPhos-Pd-G2 (4 mol %) Cs2CO3 1:1 CPME/H2O trace product
2 SPhos-Pd-G2 (4 mol %) K2CO3 1:1 CPME/H2O trace product
3 Pd2dba3/cataCXium A (4 mol %) Cs2CO3 1:1 CPME/H2O 0.50:1.0
4 (Ph3P)2PdCl2 (6 mol %) Cs2CO3 1:1 CPME/H2O 2.57:1.0
5 (Ph3P)2PdCl2 (6 mol %) Cs2CO3 1:1 toluene/H2O 2.00:1.0
6 (Ph3P)2PdCl2 (6 mol %) Cs2CO3 9:1 toluene/H2O 2.50:1.0
7 Pd(dppf)Cl2(6 mol %) Cs2CO3 1:1 toluene/H2O 3.10:1.0
8 Pd(dppf)Cl2 (6 mol %) Cs2CO3 1:1 CPME/H2O 1.85:1.0
a

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