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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Hepatology. 2014 Sep 25;60(5):1531–1540. doi: 10.1002/hep.27278

Figure 1. Changes in HCV viremia after DAA treatment and HCV J4/91 reinfection.

Figure 1

(A) After 7 years of chronic infection with the HCV J4/91 virus, chimpanzee 5835 was treated daily for 28 days the NS5a and NS5b inhibitors as depicted by the gray shaded area. Serum RNA levels were measured at three time points just before initiation of treatment and at multiple time points through 658 days of follow-up. (B) Rechallenge with HCV J4/91 was undertaken at study day 0, which was 23.5 months (658 days) after the initiation of DAA therapy. HCV RNA levels in blood were determined by the Roche COBAS Ampliprep/COBAS Taqman HCV test and data are presented as the number of international units (IU) per mL of serum.