Fig. 2.

Serum levels of IgM and IgG auto-antibodies and of total IgM, IgG and IgA. Sera were collected from WT B6 (n = 5–24; closed circles), FcμR(+) B6/lpr (n = 13–23; closed inverted triangles) and FcμR(−) B6/lpr (n = 16–28; closed diamonds) female mice at the age of 10 weeks (top), 20 weeks (middle) and 50 weeks (bottom), and were subjected to ELISA for assessment of titers of antibody against dsDNA (A). Concentrations (μg/ml) of total serum IgM, IgG and IgA are also depicted (B). Each symbol represents data from an individual mouse. *P < 0.05, **P < 0.01 and ***P < 0.001, respectively.