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. 2014 Jul 3;26(12):659–672. doi: 10.1093/intimm/dxu070

Fig. 5.

Fig. 5.

Pathological changes of kidney. (A) Representative PAS-stained kidney sections from FcμR(+) (left panel) and FcμR(−) (right panel) B6/lpr mice of 50 weeks of age at two different magnifications. Scale bars indicate 50 μm (upper panel) and 20 μm (lower panel). Note mesangial cell proliferation and increase mesangial matrix with homogeneous PAS+ substances in both groups of mice. (B) Representative immunofluorescence images of glomerular deposition of IgM (top), IgG (middle) and C3 (bottom) from FcμR(+) (left panel) and FcμR(−) (right panel) B6/lpr mice. Note the presence of immune deposits primarily in the mesangium of both groups of mice. (C) Mean fluorescence intensity (MFI) of deposition of IgM, IgG, IgA and C3 in glomeruli from FcμR(+) (closed inverted triangles) and FcμR(−) (closed diamonds) B6/lpr mice. Results are shown as arbitrary units.