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. 2014 Nov 17;9:5307–5316. doi: 10.2147/IJN.S70457

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© 2014 Jia et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Bone regeneration in the rat skull defect model. (A) microCT reconstruction and the red circle represent the region of interest. (B) Van Gieson’s staining and the red rectangle represents the region of interest. (C) New bone volume ratio. (D) New bone area ratio.

Notes: ^a–dP<0.05 versus mono siCkip-1, siFlt-1, and siNC transfection or blank sponge, respectively.

Abbreviations: BV, bone volume; TV, total volume; siNC, negative control small interfering RNA; siCkip-1, small interfering RNA targets casein kinase 2 interaction protein 1; siFlt-1, small interfering RNA targets soluble VEGF receptor 1.