TABLE 2.
Structures of M. tuberculosis STPKs available in the Research Collaboratory for Structural Bioinformatics (RCSB) Protein Database (PDB)
| Kinase | PDB ID | Notes | Reference |
|---|---|---|---|
| PknB | 1MRU | KD + short linker (1-307) in complex with ATPyS, “back-to-back” dimer | 13 |
| 1O6Y | KD (1-279) in complex with AMP-PCP, monomer | 12 | |
| 2FUM | KD (1-279) in complex with mitoxantrone, “back-to-back” dimer | 25 | |
| 3F69 | L33D/M145L/M155V mutant (PknD surrogate) with Kt5720 “front-to-front” dimer | 21 | |
| 3F61 | L33D / V222D double mutant | ||
| 2KUI | Extracellular sensor (PASTA) | 28 | |
| 2KUE | Extracellular sensor (PASTA)-NMR structures | ||
| 2KUF | |||
| 2KUD | |||
| 3ORI | L33D mutant, various conformations | 22 | |
| 3ORK | |||
| 3ORL | |||
| 3ORO | L33D mutant, no metal ion bound | ||
| 3ORP | |||
| 3ORT | |||
| 3ORM | D76A mutant | ||
| PknD | 1RWI 1RWL | Extracellular sensor domain | 53 |
| PknE | 2H34 | Apo-KD | 14 |
| PknG | 2PZI | Rubredoxin + KD + TPR domain (69 aa truncated from N-terminus) in complex with Ax20017, dimer | 29 |
| PknH | 4ESQ | Extracellular sensor domain, dimer | 70 |