TABLE 1.

Clinical and biological characteristics of apoA-I-deficient subjects and age- and sex-matched controls

	Controls	Heterozygous Subjects (n = 6)	Homozygous Subjects (n = 2)
Age, years	54 ± 11	41 ± 2	41 (40, 42)
BMI, kg/m2	24.4 ± 3.1	26.1 ± 7.0	29.3 (32.2, 26.5)
Male/female	11/0	5/1	2/0
Plasma parameters
TC, mg/dl	189 ± 24	191 ± 7	169 (142, 196)
LDL-C, mg/dl	119 ± 26	132 ± 25	145 (120, 170)
HDL-C, mg/dl	52 ± 11	21 ± 9a	4 (3, 5)b
Non-HDL-C, mg/dl	134 ± 28	171 ± 13c	164 (137, 190)
TGs, mg/dl	87 ± 27	130 ± 42c	94 (86, 101)
GPs, mg/dl	223 ± 29	267 ± 29a	209 (202, 215)
ApoB100, mg/dl	99 ± 23	114 ± 14	104 (81, 127)
ApoA-I, mg/dl	132 ± 17	79 ± 24a	0a
ApoC-III, mg/dl	7.5 ± 2.0	6.0 ± 3.0	3.3 (3.1, 3.4)b
Fasting glucose, mg/dl	91 ± 8	85 ± 10	83 (88, 78)
hsCRP, mg/l	0.60 (0.20; 4.5)	0.93 (0.37; 8.87)	9.3 (4.7, 13.8)b

Data obtained in two heterozygotes are shown as means (individual values).

^aP < 0.001; versus control subjects.

^bP < 0.01; versus control subjects.

^cP < 0.05; versus control subjects.