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1H NMR of hepatic lipids from an animal gavaged with DMSO vehicle (A) or DMSO plus SCD-1 inhibitor (B); 2H NMR of hepatic lipids from an animal gavaged with DMSO vehicle (C) or DMSO plus SCD-1 inhibitor (D). Animals treated with inhibitor show no deuterium incorporation above natural abundance in their FA olefinic protons (2 ppm), even though the concentration of unsaturated lipid by 1H NMR is unchanged.
