TABLE 3.
Age-, gender-, and risk factor-matched case-control comparison between R13G and WT S1P1
| Factor | R13G (n = 59) | WT (n = 236) | Significance |
| Age (± SEM)a | 66.49 ± 1.51 | 66.80 ± 0.83 | NS |
| Male (% total)a | 41 (69.5%) | 165 (69.9%) | NS |
| Female (% total)a | 18 (30.5%) | 71 (30.1%) | NS |
| BMI (± SEM)a | 29.37 ± 0.76 | 29.03 ± 0.42 | NS |
| HTN (% total)a | 40 (67.8%) | 163 (69.1%) | NS |
| Chol (% total)a | 46 (77.9%) | 179 (75.8%) | NS |
| FHx (% total)a | 26 (44.1%) | 103 (43.6%) | NS |
| DM (% total)a | 23 (38.9%) | 98 (41.5%) | NS |
| Smoking (% total)a | 9 (15.2%) | 33 (14.0%) | NS |
| LM (% total)b | 26 (44.1%) | 105 (44.5%) | NS |
| LAD (% total)b | 50 (84.7%) | 212 (89.8%) | NS |
| LCx (% total)b | 46 (77.9%) | 200 (84.7%) | NS |
| RCA (% total)b | 49 (83.0%) | 207 (87.7%) | NS |
| Multivessel disease (% total)b | 49 (83.0%) | 219 (93.2%) | P < 0.05 |
| Number of diseased vessels (± SEM)b | 2.98 ± 0.17 | 3.07 ± 0.06 | NS |
| Number of cardiovascular events (± SEM)b | 1.89 ± 0.20 | 1.78 ± 0.78 | NS |
| Number of post interventions (± SEM)b | 0.57 ± 0.07 | 0.62 ± 0.04 | NS |
HTN, hypertension; Chol, dyslipidemia; FHx, family history of cardiovascular diseases; DM, diabetes mellitus; LM, left main coronary artery; LAD, left anterior descending coronary artery; LCx, left circumflex coronary artery; RCA, right coronary artery.
a
Age, gender and risk factors were matched between the case (R13G mutant, n = 59) and the control (WT S1P1, n = 236).
b
Numbers of patients with no CAD and with multivessel disease (obstruction in >1 major coronary artery) are shown.