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. 2014 Aug 16;14:598. doi: 10.1186/1471-2407-14-598

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© Shapovalov et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fluoxetine administration increases BBB permeability. Fluoxetine was administered for 3 weeks before animals were injected intravenously with 2% Evan’s Blue solution. One hour after the injection, brain tissue was collected and processed as described. Tissue supernatants were analyzed by spectroscopy at 620 nm to determine Evan’s Blue absorbance. The results show significant effects of fluoxetine treatment. n = 6-7 per group, p < 0.0001.