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. 2014 Oct 7;15(10):482. doi: 10.1186/s13059-014-0482-3

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© Guo et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Two models of Myc-Max recruitment. The top panel illustrates the prevailing view of E-box recruitment of Myc-Max followed by interactions of Mediator and other factors that affect transcription. The bottom panel is an alternative view supported by the results presented here in which Myc-Max is recruited by the transcription machinery and bound with a relaxed sequence requirement to promoter DNA. We suggest that the Myc-Max occupancy of the promoter region helps keep the promoter free of nucleosomes and the resulting increased accessibility of the promoter is responsible for the amplification of gene expression caused by Myc.