Table 10.
Population-Attributable Risk (PAR) Table
| Exposure | Relative Risk | Frequency in Cases, θ | Adjusted PAR (95% Confidence Interval) |
|---|---|---|---|
| LOC387715/ARMS2 rs10490924 | |||
| TT versus GG | 61.9 | 0.34 | 0.33 (0.23–0.42) |
| TG versus GG | 5.3 | 0.39 | 0.32 (0.21–0.41) |
| Smoking (<10 vs. ≥10 pack-years) | 3.8 | 0.54 | 0.40 (0.30–0.48) |
| Smoking ≥ 10 pack-years or T allele* | 4.0 | 0.87 | 0.65 (0.60–0.70) |
| CFH CC versus TT | 18.1 | 0.34 | 0.32 (0.22–0.41) |
| Smoking ≥ 10 pack-years or T allele or CFH CC* | 10.3 | 0.90 | 0.81 (0.78–0.84) |
| LOC387715/ARMS2 rs10664316 | |||
| AT/AT versus del AT/del AT | 11.5 | 0.57 | 0.52 (0.45–0.59) |
| AT/AT versus del AT/AT | 3.5 | 0.31 | 0.22 (0.10–0.33) |
| Smoking (<10 vs. ≥10 pack-years) | 3.0 | 0.54 | 0.36 (0.26–0.45) |
| Smoking ≥ 10 pack-years or AT allele* | 2.5 | 0.94 | 0.56 (0.50–0.62) |
| CFH CC versus TT | 12.6 | 0.34 | 0.31 (0.21–0.41) |
| Smoking ≥ 10 pack-years or AT/AT (no del allele) or CFH CC* | 6.0 | 0.85 | 0.71 (0.66–0.75) |
| HTRA1 rs11200638 | |||
| AA versus GG | 98.4 | 0.32 | 0.32 (0.21–0.41) |
| AG versus GG | 6.1 | 0.41 | 0.34 (0.24–0.43) |
| Smoking (<10 vs. ≥10 pack-years) | 4.1 | 0.54 | 0.41 (0.32–0.49) |
| Smoking ≥ 10 pack-years or A allele* | 4.1 | 0.87 | 0.66 (0.60–0.70) |
| CFH CC versus TT | 19.6 | 0.34 | 0.32 (0.22–0.41) |
| Smoking ≥ 10 pack-years or A allele or CFH CC* | 10.7 | 0.91 | 0.82 (0.80–0.85) |
| HTRA1 rs2672598 | |||
| CC versus TT | 36.5 | 0.48 | 0.46 (0.38–0.54) |
| TC versus TT | 4.3 | 0.41 | 0.32 (0.21–0.41) |
| Smoking (<10 vs. ≥10 pack-years) | 3.5 | 0.54 | 0.39 (0.29–0.47) |
| Smoking ≥ 10 pack-years or C allele* | 3.5 | 0.94 | 0.67 (0.62–0.72) |
| CFH CC versus TT | 10.3 | 0.34 | 0.30 (0.20–0.40) |
| Smoking ≥ 10 pack-years or CC (no T allele) or CFH CC* | 8.0 | 0.86 | 0.75 (0.71–0.79) |
| HTRA1 rs1049331 | |||
| TT versus CC | 105.5 | 0.33 | 0.33 (0.22–0.42) |
| TC versus CC | 6.0 | 0.40 | 0.33 (0.23–0.42) |
| Smoking (<10 vs. ≥10 pack-years) | 4.1 | 0.54 | 0.41 (0.32–0.49) |
| Smoking ≥ 10 pack-years or T allele* | 4.1 | 0.87 | 0.66 (0.60–0.70) |
| CFH CC versus TT | 19.3 | 0.34 | 0.32 (0.22–0.41) |
| Smoking ≥ 10 pack-years or T allele or CFH CC* | 10.7 | 0.91 | 0.82 (0.80–0.85) |
| HTRA1 rs2293870 | |||
| CC, CT, or TT versus GG | 26.0 | 0.41 | 0.39 (0.30–0.48) |
| CG or TG versus GG | 5.9 | 0.40 | 0.33 (0.23–0.42) |
| Smoking (<10 vs. ≥10 pack-years) | 3.3 | 0.54 | 0.38 (0.28–0.46) |
| Smoking ≥ 10 pack-years or C or T allele* | 3.4 | 0.90 | 0.64 (0.58–0.68) |
| CFH CC versus TT | 13.9 | 0.34 | 0.31 (0.21–0.41) |
| Smoking ≥ 10 pack-years or C or T allele or CFH CC* | 8.0 | 0.94 | 0.82 (0.78–0.86) |
CFH = complement factor H gene.
Relative risk is estimated by conditional logistic regression adjusting for other factors.
*
This value is less than the sum of the adjusted PARs, because these risk factors are not mutually exclusive, and the relative risk used here is not adjusting for other factors.