Table 5.

Genotype and Allele Frequencies

	Affected Siblings (Index Cases)		Unaffected Siblings
	Frequency (%)	N	Frequency (%)	N
LOC387715/ARMS2
rs10490924
Genotype
TT	33.58	45	16.42	22
TG	38.06	51	32.84	44
GG	28.36	38	50.75	68
Total		134	134
Allele
T	52.61	141	32.84	88
G	47.39	127	67.16	180
Total		268		268
rs10664316
Genotype
--	11.19	15	18.66	25
--AT	31.34	42	45.52	61
AT	57.46	77	35.82	48
Total		134		134
Allele
--	26.87	72	41.42	111
AT	73.13	196	58.58	157
Total		268		268
HTRA1
rs11200638
Genotype
AA	32.09	43	15.67	21
AG	40.30	54	32.09	43
GG	27.61	37	52.2	70
Total		134		134
Allele
A	52.24	140	31.72	85
G	47.76	128	68.28	183
Total		268		268
rs2672598
Genotype
TT	11.94	16	26.12	35
TC	40.30	54	47.01	63
CC	47.76	64	26.87	36
Total		134		134
Allele
T	32.09	86	49.63	133
C	67.91	182	50.37	135
Total		268		268
rs1049331
Genotype
TT	32.84	44	15.67	21
TC	39.55	53	32.09	43
CC	27.61	37	52.24	70
Total		134		134
Allele
T	52.61	141	31.72	85
C	47.39	127	68.2	183
Total		268		268
rs2293870
Genotype
CC	0.75	1	2.24	3
TT	31.34	42	15.67	21
CG	6.72	9	9.70	13
TG	32.84	44	28.36	38
CT	8.96	12	3.73	5
GG	19.41	26	40.30	54
Total		134		134
Allele
C	8.58	23	8.96	24
T	52.23	140	31.72	85
G	39.18	105	59.33	159
Total		268		268