Table 9.

Results of Multiple Conditional Logistic Regression Analysis Showing Significant Single-Nucleotide Polymorphisms

Risk Factor	Referent	Odds Ratio (95% CI)	P Value
LOC387715/ARMS2 rs10490924 “T” is rare allele
rs10490924 TT	GG	61.91 (10.89–352.01)	0.0000033
rs10490924 TG	GG	5.32 (1.82–15.52)	0.0022
Smoking ≥ 10 pack-years	<10 pack-years	3.81 (1.84–7.91)	0.0003
CFH CC	TT	18.13 (4.20–78.22)	0.0001
CFH TC	TT	1.78 (0.72–4.40)	0.2089
LOC387715/ARMS2 rs10664316 “del AT” is rare allele
rs10664316 del AT/del AT	AT/AT	0.09 (0.02–0.36)	0.0007
rs10664316 del AT/AT	AT/AT	0.30 (0.13–0.72)	0.0069
Smoking ≥ 10 pack-years	<10 pack-years	3.00 (1.58–5.70)	0.0008
CFH CC	TT	12.64 (3.26–49.04)	0.0002
CFH TC	TT	1.56 (0.68–3.58)	0.2998
HTRA1 rs11200638 “A” is rare allele
rs11200638 AA	GG	98.41 (13.45–720.08)	0.0000062
rs11200638 AG	GG	6.05 (2.13–17.21)	0.0007
Smoking ≥ 10 pack-years	<10 pack-years	4.08 (1.93–8.63)	0.0002
CFH CC	TT	19.59 (4.36–88.03)	0.0001
CFH TC	TT	1.69 (0.67–4.26)	0.2687
HTRA1 rs2672598 “T” is rare allele
rs2672598 TT	CC	0.03 (0.01–0.14)	0.000013
rs2672598 TC	CC	0.12 (0.04–0.39)	0.0004
Smoking ≥ 10 pack-years	<10 pack-years	3.48 (1.73–7.01)	0.0005
CFH CC	TT	10.34 (2.76–38.67)	0.0005
CFH TC	TT	1.69 (0.70–4.06)	0.2428
HTRA1 rs1049331 “T” is rare allele
rs1049331 TT	CC	105.52 (14.64–760.50)	0.0000038
rs1049331 TC	CC	5.97 (2.10–16.99)	0.0008
Smoking ≥ 10 pack-years	<10 pack-years	4.09 (1.93–8.66)	0.0002
CFH CC	TT	19.29 (4.28–86.94)	0.0001
CFH TC	TT	1.67 (0.66–4.20)	0.2754
HTRA1 rs2293870 “T” and “C” are rare alleles
rs2293870 CC, CT or TT	GG	25.97 (6.32–106.66)	0.0000062
rs2293870 CG or TG	GG	5.89 (1.96–17.71)	0.0016
Smoking ≥ 10 pack-years	<10 pack-years	3.31 (1.66–6.60)	0.0006
CFH CC	TT	13.94 (3.37–57.67)	0.0003
CFH TC	TT	1.58 (0.64–3.90)	0.3227

CFH = complement factor H gene; CI = confidence interval.