Table 3.

Enantioselective Synthesis of Tetrahydroquinoxalines^a

Entry	Substrate	R1–X	Product	Yield (%)b	er
1	3a	Ph–Br	4a	79	97:3
2	3a	p-PhC(O)-C6H4-Br	4b	78	96:4
3	3a		4c	84	93:7
4	3a		4d	82	96:4
5c	3a		4e	70	93:7
6	3a		4f	74	98:2
7	3b	Ph–Br	4g	79	96:4
8	3c	Ph–Br		NR

^aConditions: 1.0 equiv 3, 2.0 equiv R–X, 2.0 equiv NaO^tBu, 2 mol % Pd₂(dba)₃, 6 mol % (S)-Siphos-PE, toluene (0.1 M), 110 °C, 12-14 h.

^bIsolated yield (average of two or more runs).

^cThe reaction was conducted at 120 °C in xylenes.

d No reaction was observed.