. 2014 Nov 24;9(11):e113211. doi: 10.1371/journal.pone.0113211

Table 2. Putative candidate genes of the DEGs associated with goose laying.

Gene	Gene ID	log2 Ratio(laying_period/ceased_period)	Up-Down-Regulation(laying_period/ceased_period)
Steroid hormone biosynthesis
cytochrome P450 3A40 (CYP3A4)	gi\|513207965\|	1.158476902	Up
testosterone 17-beta-dehydrogenase 3 (ZNF367)	gi\|513231050\|	−5.619898953	Down
beta-hydroxysteroid dehydrogenase 1 (HSD3B2)	gi\|45384115\|	−5.261921985	Down
cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)	gi\|48976108\|	−3.359829329	Down
steroid 17-alpha-hydroxylase/17,20 lyase precursor (CYP17A1)	gi\|402692072\|	−3.202412536	Down
estradiol 17-beta-dehydrogenase 1 (HSD17B1)	gi\|45382290\|	−1.429215392	Down
cytochrome P450 19A1 (CYP19A1)	gi\|48976118\|	−1.248643146	Down
Progesterone-mediated oocyte maturation
progesterone receptor (PGR)	gi\|45383981\|	1.432343028	Up
phosphoinositide 3-kinase regulatory subunit 5 (PIK3R5)	gi\|71897362\|	1.408455155	Up
adenylate cyclase type 7 (ADCY7)	gi\|513203244\|	1.319161648	Up
fizzy-related protein homolog isoform 1 (CDH1-A)	gi\|493795026\|	1.278954323	Up
serine/threonine-protein kinase PLK1 (PLK1)	gi\|71894744\|	1.011346258	Up
uncharacterized protein LOC416455 (C7ORF50)	gi\|513207883\|	−1.534242869	Down
LOW QUALITY PROTEIN: adenylate cyclase type 2 (ADCY2)	gi\|513171076\|	−1.518812828	Down
heat shock protein HSP 90-alpha (HSP90AA1)	gi\|157954046\|	−1.353494256	Down
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)	gi\|513164084\|	−1.249276602	Down
N-chimaerin (CHN1)	gi\|61098445\|	−1.162811275	Down
GnRH signaling pathway
cytosolic phospholipase A2 epsilon-like	gi\|513188970\|	2.695250609	Up
protein kinase C beta type (PRKCB)	gi\|513209045\|	1.328811818	Up
adenylate cyclase type 7 (ADCY7)	gi\|513203244\|	1.319161648	Up
dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)	gi\|497815303\|	1.306754897	Up
voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D)	gi\|402232741\|	−1.676888932	Down
LOW QUALITY PROTEIN: adenylate cyclase type 2 (ADCY2)	gi\|513171076\|	−1.518812828	Down
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)	gi\|513164084\|	−1.249276602	Down
copine-8 (CPNE8)	gi\|313747427\|	−1.166180986	Down
Oocyte meiosis
progesterone receptor (PGR)	gi\|45383981\|	1.432343028	Up
adenylate cyclase type 7 (ADCY7)	gi\|513203244\|	1.319161648	Up
serine/threonine-protein kinase PLK1 (PLK1)	gi\|71894744\|	1.011346258	Up
structural maintenance of chromosomes protein 1B (SMC1B)	gi\|513160707\|	−1.624471683	Down
LOW QUALITY PROTEIN: adenylate cyclase type 2 (ADCY2)	gi\|513171076\|	−1.518812828	Down
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)	gi\|513164084\|	−1.249276602	Down
Steroid biosynthesis
7-dehydrocholesterol reductase (DHCR7)	gi\|313747478\|	−2.132003871	Down
24-dehydrocholesterol reductase (DHCR24)	gi\|71896814\|	−1.780922052	Down
methylsterol monooxygenase 1 (MSMO1)	gi\|57530154\|	−1.744980748	Down
Calcium signaling pathway
glutamate [NMDA] receptor subunit epsilon-3-like (GRIN2C)	gi\|513214949\|	3.069035476	Up
platelet-derived growth factor receptor beta (PDGFRB)	gi\|513207013\|	2.483913376	Up
protein AHNAK2-like	gi\|513190197\|	2.262291202	Up
protein kinase C beta type (PRKCB)	gi\|513209045\|	1.328811818	Up
adenylate cyclase type 7 (ADCY7)	gi\|513203244\|	1.319161648	Up
voltage-dependent T-type calcium channel subunit alpha-1I (CACNA1I)	gi\|513159170\|	1.316738986	Up
inositol-trisphosphate 3-kinase B (ITPKB)	gi\|513174490\|	1.297879958	Up
voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H)	gi\|513208286\|	1.161115576	Up
voltage-dependent N-type calcium channel subunit alpha-1B (CACNA1B)	gi\|45383553\|	1.100472667	Up
lutropin-choriogonadotropic hormone receptor precursor (LHCGR)	gi\|45384387\|	−2.357780254	Down
type-1 angiotensin II receptor (AGTR1)	gi\|119943121\|	−1.853766694	Down
voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D)	gi\|402232741\|	−1.676888932	Down
LOW QUALITY PROTEIN: adenylate cyclase type 2 (ADCY2)	gi\|513171076\|	−1.518812828	Down
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	gi\|513191366\|	−1.380738319	Down
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)	gi\|513164084\|	−1.249276602	Down
copine-8 (CPNE8)	gi\|313747427\|	−1.166180986	Down
G-protein coupled receptor signaling pathway
neuropeptide Y receptor type 1 (NPY1R)	gi\|71895854\|	1.234524222	Up
probable G-protein coupled receptor 133 (GPR133)	gi\|513209875\|	2.254811236	Up
diacylglycerol kinase zeta (DGKZ)	gi\|71894854\|	1.067874353	Up
low-density lipoprotein receptor-related protein 1 precursor (LRP1)	gi\|45382556\|	1.41426879	Up
Agrin C-terminal 22 kDa fragment (AGRN)	gi\|45382976\|	1.005732177	Up
diacylglycerol kinase beta-like (DGKG)	gi\|513199158\|	1.178410829	Up
filamin-A (FLNA)	gi\|45383034\|	1.326016799	Up
adenylate cyclase type 7 (ADCY7)	gi\|513203244\|	1.319161648	Up
alpha-2A adrenergic receptor (ADRA2A)	gi\|513191949\|	2.134988549	Up
VPS10 domain-containing receptor SorCS2 (SORCS2)	gi\|513184939\|	1.409219902	Up
D(2) dopamine receptor (DRD2)	gi\|164518969\|	1.792318027	Up
gamma-aminobutyric acid receptor subunit alpha-1 precursor (GABRA1)	gi\|319655698\|	−1.42313234	Down
neuron-specific protein family member 2-like isoform 1	gi\|513206640\|	−2.356864548	Down
gamma-aminobutyric acid receptor subunit gamma-4 precursor (GABRE)	gi\|46048734\|	−1.882084965	Down
lutropin-choriogonadotropic hormone receptor precursor (LHCGR)	gi\|45384387\|	−2.357780254	Down
type-1 angiotensin II receptor (AGTR1)	gi\|119943121\|	−1.853766694	Down
G protein-coupled receptor kinase 5 (GRK5)	gi\|513192176\|	−1.585133535	Down
LOW QUALITY PROTEIN: diacylglycerol kinase theta (DGKQ)	gi\|513232846\|	−1.013456725	Down
voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D)	gi\|402232741\|	−1.676888932	Down
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	gi\|513191366\|	−1.380738319	Down
mu-type opioid receptor-like, partial (OPRM1)	gi\|513176530\|	−8.310406357	Down
LOW QUALITY PROTEIN: adenylate cyclase type 2 (ADCY2)	gi\|513171076\|	−1.518812828	Down
dopaminergic synapse
D(2) dopamine receptor (DRD2)	gi\|164518969\|	1.792318027	Up
protein kinase C beta type (PRKCB)	gi\|513209045\|	1.328811818	Up
voltage-dependent N-type calcium channel subunit alpha-1B (CACNA1B)	gi\|45383553\|	1.100472667	Up
guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11 (GNG11)	gi\|487442755\|	−1.075578437	Down
neuron-specific protein family member 2-like isoform 1	gi\|513206640\|	−2.356864548	Down
voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D)	gi\|402232741\|	−1.676888932	Down
uncharacterized protein LOC416455	gi\|513207883\|	−1.534242869	Down
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)	gi\|513164084\|	−1.249276602	Down
copine-8 (CPNE8)	gi\|313747427\|	−1.166180986	Down
N-chimaerin (CHN1)	gi\|61098445\|	−1.162811275	Down
MAPK signaling pathway
cytosolic phospholipase A2 epsilon-like	gi\|513188970\|	2.695250609	Up
platelet-derived growth factor receptor beta (PDGFRB)	gi\|513207013\|	2.483913376	Up
dual specificity protein phosphatase 4 (DUSP4)	gi\|45382296\|	2.176808724	Up
protein kinase C beta type (PRKCB)	gi\|513209045\|	1.328811818	Up
filamin-A (FLNA)	gi\|45383034\|	1.326016799	Up
voltage-dependent T-type calcium channel subunit alpha-1I (CACNA1I)	gi\|513159170\|	1.316738986	Up
TGF-beta receptor type-2 precursor (TGFBR2)	gi\|45382188\|	1.310075255	Up
dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)	gi\|497815303\|	1.306754897	Up
filamin-B (FLNB)	gi\|71896430\|	1.217226477	Up
voltage-dependent T-type calcium channel subunit alpha-1H (CACNA1H)	gi\|513208286\|	1.161115576	Up
voltage-dependent N-type calcium channel subunit alpha-1B (CACNA1B)	gi\|45383553\|	1.100472667	Up
serum response factor (SRF)	gi\|356460963\|	1.090757769	Up
nuclear factor NF-kappa-B p105 subunit (NFKB1)	gi\|45384085\|	1.084126722	Up
stathmin-2 (STMN2)	gi\|49170101\|	−3.928021249	Down
keratinocyte growth factor (FGF7)	gi\|60302701\|	−2.27197565	Down
fibroblast growth factor 12 (FGF12)	gi\|45382434\|	−2.240405571	Down
voltage-dependent L-type calcium channel subunit alpha-1D (CACNA1D)	gi\|402232741\|	−1.676888932	Down
platelet-derived growth factor subunit B precursor (PDGFB)	gi\|326693934\|	−1.449973952	Down
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)	gi\|513164084\|	−1.249276602	Down
tyrosine-protein phosphatase non-receptor type 5 (PTPN5)	gi\|513186533\|	−1.227581531	Down
microtubule-associated protein tau (MAPT)	gi\|312836786\|	−1.185761355	Down
copine-8 (CPNE8)	gi\|313747427\|	−1.166180986	Down
N-chimaerin (CHN1)	gi\|61098445\|	−1.162811275	Down
neuron navigator 3 (NAV3)	gi\|433660829\|	−1.050703769	Down