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. 2014 Nov 18;15(1):978. doi: 10.1186/1471-2164-15-978

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© Shao et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Diagram of extracting DNA methylation pattern and calculation of entropy. Step 1. Mapping paired-end DNA methylation reads to Human reference; Step 2. Extracting DNA methylation calls; Step 3. Obtaining 4 contiguous CpG dinucleotides involved segments; Step 4. Calculating DNA methylation entropy for each segment. Filled and open circles represent methylated and unmethylated CpG dinucleotides, respectively.