Table 1.
Evidence that selection affects codon usage bias in humans. Before (After) controlling for potential CpG mis-polarization.
| Polymorphic | Fixed1 | P (Fixed) | Chisq | P | Chisq/N | |
|---|---|---|---|---|---|---|
| Exons | ||||||
| Preferred→unpreferred | 10,249 (10,249) | 7729 (7729) | 0.43 (0.43) | |||
| Unpreferred→preferred | 3957 (2859) | 3731 (2487) | 0.49 (0.47) | 66.62 (20.71) | 10−15 (10−5) | 2.60 (0.89) |
| Intron | ||||||
| Preferred→unpreferred | 690,248 (690,248) | 366,993 (366,993) | 0.35 (0.35) | |||
| Unpreferred→preferred | 609,530 (521,822) | 345,218 (285,076) | 0.36 (0.35) | 458.46 (76.7) | 10−15 (10−15) | 0.23 (0.04) |
1
Polarized by comparison of human segregating sites to chimpanzee + gorilla genomes.