Table 5.
Risk factors associated with recurrence-free survival
| Univariate | Multivariate | ||||
|---|---|---|---|---|---|
| HR (95% CI) | p | HR (95% CI) | P | ||
| Age (years) | < 60 vs. ≥ 60 | 1.2 (0.6 − 2.4) | 0.5 | NA | |
| Gender | Male vs. female | 1.2 (0.5 − 2.6) | 0.7 | NA | |
| Tumor location | Upper, mid vs. low | 1.4 (0.7 − 2.7) | 0.4 | NA | |
| Operation type | LAR vs. APE or Hartmann | 0.6 (0.3 − 1.6) | 0.4 | NA | |
| Duration (preoperative CRT to surgery) (week) | <6 vs. ≥6 | 0.8 (0.4 − 1.6) | 0.5 | NA | |
| Tumor diameter (cm) | <3 vs. ≥3 | 1.5 (0.8 − 3.1) | 0.2 | NA | |
| ypTNM | pCR,I vs. II,III,IV | 3.4 (1.7 − 6.8) | 0.001 | 3.1 (1.5 − 6.2) | 0.002 |
| CEA (ng/mL) | < 5 vs. ≥ 5 | 1.7 (0.8 − 3.7) | 0.2 | 1.3 (0.6 − 2.9) | 0.5 |
| NLR | < 3 vs. ≥ 3 | 3.6 (1.5 − 8.9) | 0.01 | 2.8 (1.1 − 6.8) | 0.03 |
HR, hazard ratio; CI, confidence interval; NA, not applied; LAR, low anterior resection; APE, abdominoperineal excision; CRT, Chemoradiation; pCR, pathologic complete response; CEA, carcinoembryonic antigen; NLR, neutrophil-lymphocyte ratio.