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. 2014 Nov 24;9(11):e113622. doi: 10.1371/journal.pone.0113622

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© 2014 Zhang et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

The trajectories of the molecular dynamics simulations were analyzed using principal component analysis (PCA), which separates out the motions of the CaSR ECD into principal modes ranked according to their relative contributions. The first three principal modes were included in the present study to analyze the four CaSR mutants and the wild type: WT (black), L173F (green), presence P221L (magenta), L173P (red), P221Q (blue).