Table 2.
Covariates | Odds ratio | 95% Confidence interval | P-value |
---|---|---|---|
Age (years) | 1.03 | 0.99, 1.06 | 0.08 |
Sex | 1.08 | 0.56, 2.07 | 0.82 |
Response to MMT (% positive opioid urine tests) | 1.02 | 1.00, 1.03 | 0.01 |
Infectious disease status | 1.40 | 0.65, 3.00 | 0.38 |
Methadone dose (mg/d) | 1.00 | 0.99, 1.01 | 0.94 |
Presence of inflammatory medications | 1.26 | 0.41, 3.92 | 0.69 |
TNF-α | 0.69 | 0.37, 1.30 | 0.25 |
IFN-γ | 2.02 | 1.17, 3.50 | 0.01 |
IL-6 | 1.18 | 0.60, 2.32 | 0.63 |
IL-1ra | 0.84 | 0.51, 1.37 | 0.49 |
CCL2 | 1.60 | 0.88, 2.88 | 0.12 |
IL-8 | 0.73 | 0.43, 1.21 | 0.22 |
IL-10 | 1.01 | 0.69, 1.48 | 0.97 |
Notes: Sex is interpreted as female, in reference to males. Infectious disease status was a binary measure of the presence of HIV and/or hepatitis. All cytokine measurements have been log-transformed, and the original measurements were in picograms per milliliter.
Abbreviations: MMT, methadone maintenance treatment; IL, interleukin; IL-1ra, interleukin 1 receptor antagonist; TNF, tumor necrosis factor; CCL2, chemokine (C–C motif) ligand 2; HIV, human immunodeficiency virus; IFN, interferon.