Table 3.
Genotype and allele frequencies of three SNPs in the MMPs gene between ESCC patients and controls.
| Polymorphisms | Controls n=132 (%) | ESCC patients n=132 (%) | OR (95% CI) | p |
|---|---|---|---|---|
| MMP1 −1607 1G/2G | ||||
| Genotypes | ||||
| 2G2G | 87 (65.91) | 81 (61.36) | 1.00 (Ref) | |
| 2G1G | 40 (30.30) | 41 (31.06) | 1.10 (0.65–1.87) | .72 |
| 1G1G | 5 (3.9) | 10 (7.58) | 2.15 (0.70–6.55) | .17 |
| Alleles | ||||
| 2G | 214 (84.47) | 203 (76.89) | 1.00 (Ref) | |
| 1G | 50 (15.53) | 61 (23.11) | 1.29 (0.85–1.96) | .24 |
| MMP3 −1612 5A/6A | ||||
| Genotypes | ||||
| 6A6A | 65 (49.24) | 40 (30.30) | 1.00 (Ref) | |
| 6A5A | 61 (46.21) | 72 (54.55) | 1.92 (1.14–3.23) | .01 |
| 5A5A | 6 (4.55) | 20 (15.15) | 5.42 (2.01–14.63) | <.001 |
| Alleles | ||||
| 6A | 191 (72.35) | 152 (57.58) | 1.00 (Ref) | |
| 5A | 73 (27.65) | 112 (42.42) | 1.93 (1.34–2.77) | <.001 |
| MMP9 −1562 C/T | ||||
| Genotypes | ||||
| CC | 92 (69.70) | 84 (63.64) | 1.00 (Ref) | |
| CT | 34 (37.98) | 38 (28.79) | 1.22 (0.71–2.12) | .47 |
| TT | 6 (4.01) | 10 (7.58) | 1.85 (0.64–5.24) | .26 |
| Alleles | ||||
| C | 218 (82.58) | 206 (78.03) | 1.00 (Ref) | |
| T | 46 (17.42) | 58 (21.97) | 1.33 (0.87–2.05) | .19 |
Ref – reference category.