Fig. 4.
a Effect of AZ64 alone or in combination with local radiation on SY5Y-TrkB xenografts. Neuroblastoma xenografts were grown on the hindlimbs of mice and killed when they reached 1 cm3. Treatment with AZ64 had a similar effect on inhibiting growth as treatment with local radiation, and both were significantly different than the vehicle control (p < 0.0001). However, the combination of AZ64 plus radiation caused a much more dramatic and significant inhibition of tumor growth compared to either AZ64 or radiation alone (p = 0.0043 and p < 0.0001, respectively). b Survival analysis. There was a modest prolongation of survival for mice treated with AZ64 alone compared to the vehicle control, and there was a greater prolongation of survival with local radiation. However, the combination of AZ64 plus radiation significantly improved the EFS compared to that of animals treated with either treatment alone (p = 0.0006)