Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Dec;144(6):545–560. doi: 10.1085/jgp.201411172

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 Herold et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 3. — Na⁺ channel steady-state inactivation. Na⁺ channel availability (or h_∞) was tested using a double-pulse protocol with a 300-ms prepulse ranging from −120 to −30 mV in 10-mV steps, followed by a 10-ms test pulse to 0 mV (inset at ISO traces shows stimulation protocol). Peak I_Na was normalized (I_Na/I_Namax), plotted against prepulse potential, and fitted with a two-state Boltzmann distribution to calculate V_1/2 (see Materials and methods for details). (Left) Families of Na⁺ current traces in the absence (black traces, control) or presence (colored traces, drug) of anesthetics at 1 MAC. (Right) Fitted data in the absence (open circles, dotted line) or presence (full colored circles, straight black line) of anesthetic, or after washout (straight gray line). All anesthetics caused a significant left-shift of V_1/2 with values displayed next to each graph (see Table 3). Data are mean ± SD; n = 5–7.