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. 2014 Dec;144(6):503–512. doi: 10.1085/jgp.201411287

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© 2014 MacLean et al.

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Figure 1. — TARPs rescue the gating of T686S/A. (A) Structure of GluA2 LBD with glutamate bound, indicating the Thr686 position and its interactions with neighboring residues (Protein Data Bank accession no. 1FTJ). (B) Representative responses from GluA2 wild-type (left) or T686A (right) alone or coexpressed with γ-2 (bottom) evoked by quisqualate (gray) or glutamate (black or red). (C) Mean ± SEM ratio from experiment in B performed in the continual presence (left) or absence (right) of 100 µM CTZ for wild-type, T686S, or T686A constructs. n values are given in brackets.