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Effect of decompressive craniectomy (DC) and local hypothermia (LH) alone or in combination (HC) on BBB disruption. Data are expressed as mean ± SEM. N= 4 in each group. Spectrophotometry absorption in 620 nm reveals blood brain barrier disruption and Evans blue penetration. * P< 0.05 in compare with control group. ** P< 0.01 in compare with control group
