Figure 3.

Cytokine levels of brain and splenocytes in the mice induced with experimental autoimmune encephalomyelitis and receiving genistein (300 mg/kg) and DMSO either after the appearance of the first clinical sign or in late phase of disease. The TNF-α, IFN-γ, IL-12, and IL-10 levels were assessed in splenocytes (A) and the brain (B). All data expressed as the mean± SEM. ** P<0.005 and * P<0.05 compared to DMSO administration at the onset of disease, †P<0.05and ††P<0.005 compared to DMSO at late phase, § P<0.05 and §§ P<0.005 compared to genistein at late phase