Table 3.
EBV-positive lymphomas and latency types and their association with immunocompromised state
| Lineage | Immunocompetence of patients | Entity | Latency type |
|---|---|---|---|
| B cell | Competent | Classical Hodgkin Lymphoma | 2 |
| Endemic Burkitt Lymphoma | 0/1 | ||
| Sporadic Burkitt Lymphoma | 0/1 | ||
| EBV + DLBCL of the elderly | Variable | ||
| EBV + DLBCL associated with chronic inflammation (Pyothorax lymphoma) | Predominantly 3 | ||
| Compromised | Primary effusion lymphoma | 0/1 | |
| Plasmablastic lymphoma | 0/1 | ||
| Lymphomatoid Granulomatosis Grade 3 and DLBCL arising from the former | 3 | ||
| Monomorphic PTLDa | Variable | ||
| Lymphomas associated with HIV infectiona | Variable | ||
| Lymphoproliferative disease associated with primary immune disordersa | Variable | ||
| Other iatrogenic immunodeficiency-associated lymphoproliferative disordersa | 3 | ||
| T cell | Competent | Angioimmunoblastic T cell lymphoma | 0/1 or 2 |
| Extranodal NK/T cell lymphoma | 2 | ||
| Compromised | EBV-positive T cell lymphoproliferative disease of childhood and young adultsb | Variable |
aDiseases under this category are further specified according to histopathology
bThe immunodeficiency in many of these young patients is postulated but not always objectifiable
DLBCL diffuse large B cell lymphoma, PTLD posttransplant lymphoproliferative disease