Table 4.

Differential diagnostic of polymorphic EBV-positive lymphoproliferative disease (LPD) compared to Hodgkin Lymphoma

Feature	Hodgkin Lymphoma	Polymorphic EBV + LPD
Histomorphology	Mixed cellularity infiltration with Hodgkin (−like) cells, necrosis
	Predominant epitheloid cells and eosinophils	Predominant plasmablasts, plasmacells, angiotropism
Immunophenotype of large cells	CD30 > CD20	CD20 > CD30
Expression of EBV antigens	• EBER + cells equal to LMP1 + cells • EBER + large cells only • EBNA2 negative	• EBER + cells more than LMP1 + cells • EBER + small and large cells • EBNA2 +/−
Clinical scenario	Predominant immunocompetent	Predominant immunocompromised
Site	• Mediastinum • Nodal> > extranodal	• Extranodal> > nodal • Mucosa