Table 5.
Recommendations for selecting tissue specimen and methods for EBV testing
| Lymphoma | Nodal and extranodal lymphatic tissue not presenting overt lymphoma (polymorphic LPD) | |
|---|---|---|
| Histopathological features | Clinical context | |
| Testing by EBER | Testing by EBER | Testing by EBER |
| B cell lymphomas | ||
| • Endemic Burkitt Lymhoma | • Hodgkin-like large cells and Hodgkin or Reed-Sternberg cells | • Inherited immunodeficiency |
| • Plasmablastic lymphoma | ||
| • Primary effusion lymphoma | • Posttransplantation | |
| • Pyothorax associated lymphoma | ||
| • DLBCL with histological features suspicious for EBV association | • Necrosis | • Drug induced immunocompromised state |
| • Angiotropism of blastic cells | ||
| • Any monomorphic PTLD | ||
| • Lymphomatoid granulomatosis | • Plasmablastic infiltrate | • HIV infection |
| T cell lymphomas | ||
| • AILT | ||
| • Extranodal NK/T cell lymphoma | ||
| • EBV-positive T cell lymphoproliferative disease of childhood and young adults | ||
| Testing by EBER or LMP | ||
| • Hodgkin Lymphoma | ||
| Testing by EBER, LMP1 and EBNA2 | ||
| • Differential diagnosis between Hodgkin lymphoma and PTLD | ||
PTLD posttransplantation lymphoproliferative disease, AITL angioimmunoblastic T cell lymphoma