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. Author manuscript; available in PMC: 2015 Oct 23.
Published in final edited form as: Cell. 2014 Oct 23;159(3):691–696. doi: 10.1016/j.cell.2014.09.027

Figure 3. The Insulin Receptor Antagonist S961 Causes Glucose Intolerance and Beta Cell Growth in Angptl8−/− and Wild-Type Mice.

Figure 3

(A) Non-fasted plasma glucose in Angptl8−/− and WT mice continuously treated with the insulin receptor antagonist S961 (20 nMol/week) or vehicle for 13 days.

(B) Non-fasted plasma insulin on days 0 and 13 in Angptl8−/− and WT mice treated with S961 (20 nMol/week) or vehicle.

(C) Oral glucose tolerance test in Angptl8−/− and WT mice treated with S961 (20 nMol/week) or vehicle at day 11 of the study.

(D) Beta cell area as a percentage of total pancreas area in Angptl8−/− and WT mice treated with S961 (20 nMol/week) or vehicle for 13 days. See also Figure S2.

All groups had 7-10 animals. **p < 0.001; ***p < 0.0005; ****p < 0.0001. Values are mean ± SEM.