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. Author manuscript; available in PMC: 2015 Oct 23.
Published in final edited form as: Cell. 2014 Oct 23;159(3):676–690. doi: 10.1016/j.cell.2014.09.050

Figure 1. Landscape of Genomic Alterations in 402 Papillary Thyroid Carcinomas.

Figure 1

(A) Mutation density (mutations/Mb) across the cohort. (B) Tumor purity, patient age, gender, history of radiation exposure, risk of recurrence, MACIS score, histological type, and BRS score. (C) Number and frequency of recurrent mutations in genes (left) ranked by MutSig significance (right), gene-sample matrix of mutations (middle) with TERT promoter mutations (bottom). (D) Number and frequency of fusion events (left), gene-sample matrix of fusions across the cohort (middle). (E) Number and frequency of SCNAs (left), chromosome-sample matrix of SCNAs across the cohort (middle) with focal deletions in BRAF and PTEN (bottom), GISTIC2 significance (right). (F) Driving variant types across the cohort. Samples were sorted by driving variant type with dark matter on the left. See also Figures S1, S2, S3, S4 and Tables S1, S2, S3, S4A, and S5A,B,E.