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. 2014 Nov 1;5(4):166–173.

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This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of the bone marrow derived mesenchymal stem cell (BM-MSCs) on histopathological changes induced by CCl₄ in rats. A: (H&E ×100) Liver section of normal rats showing normal hepatocytes with prominent nucleus, cytoplasm and central vein; B: (H&E ×250) Liver sections of CCl₄-treated rats showing fatty chain, necrosis, infiltration of inflammatory cells; C: (H&E ×250) Liver sections of the rats treated with MSC showing well brought out central vein hepatocytes with well-preserved cytoplasm, normal hepatocytes with prominent nucleus. (H: hepatocyte, CV: central vein, N: nucleus, F: foamy macrophage cells, FC: fatty chain, NC: necrosis, I: infiltration of inflammatory cells, BD: ballooning degeneration).A: Control (0.5 mL/kg olive oil ip); B: CCl₄ (0.5 mL/kg ip); C: MSC (106 cell in 1 mL PBS infusion in liver).