Table 1.
Effect of the bone marrow-derived mesenchymal stem cell (BM-MSCs) on histopathological liver damages induced by CCl4 in rats
| Groups | Ballooning Degeneration | Fatty change | Hepatocyte necrosis | Inflammation | Fibrosis |
|---|---|---|---|---|---|
| Control | 0 | 0 | 0 | 0 | __ |
| CCl4 | ++ | + | +++ | + | Many foamy macrophages and old necrosis |
| CCl4 + MSC | 0 | 0 | 0 | 0 | __ |
0: absent +: mild ++: moderate +++: severe
Rats were injected with CCl4 (1 mL/kg, ip 1:1 in olive oil) twice per week for 8 weeks. Four weeks after the first injection MSC was infused to their livers locally. The injection of CCl4 was continued until the end of 8th week. Values are mean±SD of 6 rats per group.