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. Author manuscript; available in PMC: 2015 Nov 6.
Published in final edited form as: Cell. 2014 Nov 6;159(4):814–828. doi: 10.1016/j.cell.2014.10.026

Figure 3. Temporal dependence of T cell distribution varies by subset and compartment.

Figure 3

Lymphocyte frequency was quantified in 9 tissues from donors aged 3 to 73. (A) Heatmap of CD4+ and CD8+ T cell subset frequency (ranging from 0% (blue) to 100%, (red)) in individual donors from youngest (white) to oldest (black), from blood to lymphoid to mucosal sites. (B) Spearman correlation analysis of changes in lymphocyte tissue distribution with increasing age shows temporal changes in subset distribution in circulating and lymphoid sites. Correlation strength and directionality (r=−1, left to r=+1, right) is shown for each tissue ordered from blood to lymphoid to mucosal tissues. Correlation significance for each tissue is denoted by shading (p<0.05, striped; p<0.01, gray; p<0.001, black). Individual r- and p-values are listed in Table S5.) (C) Ex vivo analysis of proliferation of naïve, TCM, and TEM CD4 T cell subsets in different tissue sites. Ki67 expression by CD4+ naïve (red), TCM (blue), and TEM (black) CD3+ T cell subsets in blood, ILN, MLN, and jejunum from Donor 93. Compiled Ki67 data from multiple donors are in Figure S3B.