Table 3.

Drug and/or vaccine targets prioritization parameters and functional annotation of the six essential host homologous putative targets.

Gene and protein codes	Official full name	Number of cavities with Drug Scorea > 0.80	Number of cavities with Drug Scorea > 0.60 and < 0.80	Mol. Wt (KDa)b	Functionsc	Cellular componentd	Pathwayse	Virulencef
Cp1002_0385 Adk	Adenylate kinase	1	0	24.120	MF: Kinase, Transferase, ATP binding BP: Nucleotide biosynthesis EC 2.7.4.3	Cytoplasm	Purine metabolism; AMP biosynthesis via salvage pathway	Yes
Cp1002_0692 GapA	Glyceraldehyde-3-phosphate dehydrogenase A	2	1	51.918	MF: Oxidoreductase, NAD binding, NADP binding, BP: glucose metabolic process EC 1.2.1.13	Cytoplasm	Glycolysis/Gluconeogenesis	Yes
Cp1002_0728 GlyA	Serine hydroxymethyltransferase	2	1	46.187	MF: Methyltransferase, Transferase BP: Amino-acid biosynthesis One-carbon metabolism EC 2.1.2.1	Cytoplasm	Amino-acid biosynthesis; glycine biosynthesis; One-carbon metabolism; tetrahydrofolate interconversion.	Yes
Cp1002_0738 FumC	Fumaratehydratase class II	2	0	49.767	MF: Lyase BP: Tricarboxylic acid cycle EC 4.2.1.2	Cytoplasm	Carbohydrate metabolism; tricarboxylic acid cycle; (S)-malate from fumarate	Yes
Cp1002_1005 Gnd	6-phosphogluconate dehydrogenase	3	5	53.669	MF: Oxidoreductase BP: Pentose shunt EC 1.1.1.44	Cytoplasm	Carbohydrate degradation; pentose phosphate pathway;	No
Cp1002_1042 AspA	Aspartate ammonia-lyase	2	4	52.277	MF: Lyase EC 4.3.1.1	Cytoplasm	Alanine, aspartate and glutamate metabolism, Nitrogen metabolism	Yes

^aDruggability predicted with DoGSiteScorer software. A druggability score above 0.60 is usually considered, but a score above 0.80 is favored [48].

^bMolecular weight was determined using ProtParam tool (http://web.expasy.org/protparam/).

^cMolecular function (MF) and biological process (BP) for each target protein was determined using UniProt.

^dCellular localization of pathogen targets was performed using CELLO.

^eKEGG was used to find the role of these targets in different cellular pathways.

^fPAIDB was used to check if the putative targets are involved in pathogen's virulence.