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Electrochemistry of daunomycin on DNA-modified electrodes with and without intervening mismatches. The total charge calculated from cyclic voltammograms of electrodes with well matched DNA as well as with DNA containing a variety of mismatches is all shown. Daunomycin shows a preference for intercalation at 5′-GC′-3′ steps in the DNA duplex. As can be seen, the signal differential between well matched DNA and DNA containing various mismatches can be small with this method.
