Table 3.
Dosimetric factors for constrictors: univariate logistic regression analysis
| Structures | Dysphagia | Constraints | Volume (cm3) and median (range) | Univariate analysis |
||
|---|---|---|---|---|---|---|
| OR | p-value | 95% CI | ||||
| SPC | Acute 3 months 6 months |
Dmax 60 Dmean 50 V50 V55 V65 Dmax 60 Dmean 50 V50 V55 V65 Dmax 60 Dmean 50 V50 V55 V65 |
11.3 (10.8–12.4) | 3.18 1.875 1.55 2.16 1.05 12.52 9.6 6.78 10 2.25 1.86 9.33 NA NA 4.37 |
0.197 0.450 0.702 0.449 1.00 0.01 0.006 0.007 0.001 0.304 0.65 0.03 0.027 0.01 0.117 |
0.38–11.6 0.41–8.51 0.34–7.02 0.46–10.16 0.18–5.97 1.48–105.58 1.89–48.6 1.64–28.04 2.38–12.01 0.60–8.42 0.33–10.41 0.99–87.38 NA NA 0.74–25.8 |
| MPC | Acute 3 months 6 months |
Dmax 60 Dmean 50 V50 V55 V65 Dmax 60 Dmean 50 V50 V55 V65 Dmax 60 Dmean 50 V50 V55 V65 |
2.02 (1.70–2.64) | 3.18 8.5 13.25 9.1 NA 12.52 7.52 4.2 2.71 2.36 1.86 3.26 4.77 5.75 0.51 |
0.197 0.01 0.008 0.05 0.08 0.009 0.013 0.039 0.144 0.204 0.65 0.39 0.204 0.189 1 |
0.68–14.88 1.50–47.96 1.48–116.26 1.03–80.08 NA 1.48–105.58 1.48–38.07 1.13–15.49 0.81–90 0.66–8.35 0.33–10.41 0.35–30.7 0.51–44.32 0.61–53.42 0.054–4.89 |
| IPC | Acute 3 months 6 months |
Dmax 60 Dmean 50 V40 V50 V55 V65 Dmax 60 Dmean 50 V40 V50 V55 V65 Dmax 60 Dmean 50 V40 V50 V55 V65 |
5.4 (4.2–5.8) | 2.06 1.42 2.53 1.09 1.09 2.30 1.14 0.81 0.86 0.58 0.58 0.4 1.07 1.44 2.41 0.86 0.86 NA |
0.43 0.711 0.24 1.00 1.00 0.44 1 0.772 1 0.39 0.39 0.23 1 1 0.65 1 1 NA |
0.45–9.41 0.31–6.40 0.55–11.69 0.24–4.89 0.24–4.89 0.42–12.67 0.34–3.83 0.25–2.59 0.25–2.97 0.18–1.87 0.18–1.87 0.11–1.40 0.17–6.54 0.23–8.73 0.25–22.66 0.15–4.80 0.15–4.80 NA |
| Crico | Acute 3 months 6 months |
Dmax 60 Dmean 50 V40 V50 V55 V65 Dmax 60 Dmean 50 V40 V50 V55 V65 Dmax 60 Dmean 50 V40 V50 V55 V65 |
1.4 (1.2–1.8) | NA 1.66 3.18 2.75 3.73 NA 0.43 0.66 1.13 0.59 0.43 0.46 NA 0.95 0.86 1.15 0.37 NA |
0.04 0.7 0.197 0.277 0.411 0.176 0.35 0.56 1 0.55 0.35 0.33 0.159 1 1 1 0.64 0.314 |
NA 0.35–7.8 0.68–14.88 0.50–15.07 0.42–33.07 NA 0.11–1.63 0.21–2.11 0.31–4.02 0.18–1.92 0.11–1.63 0.1–1.95 NA 0.17–5.26 0.14–5.33 0.2–6.35 0.039–3.49 NA |
CI, confidence interval; Crico, cricopharyngeal muscle; Dmax, maximum dose; Dmean, mean dose; IPC, interior constrictor muscle; MPC, middle constrictor muscle; NA, OR not estimable; OR, odds ratio; SPC, superior constrictor muscle; V40, volume structure receiving ≥40 Gy; V50, volume structure receiving ≥50 Gy; V55, volume structure receiving ≥55 Gy; V60, volume structure receiving ≥60 Gy.
p-value estimated with Fisher’s exact test.