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. 2014 Nov 18;5:5399. doi: 10.1038/ncomms6399

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(a) Michaelis–Menten plots showing the catalytic rate of USP4 FL, CD, ΔDUSP, Δlinker and Δinsert as a function of substrate concentration (error bars represent s.e.m. for at least three independent replicates). The domain representation of USP4 indicating the DUSP domain, the insert and the linker is given as reference. (b) Surface plasmon resonance (SPR) traces of DUSP–Ubl at different concentrations binding to USP4 CD, insert and D1D2. The overlay of the normalized responses is given in the lower right panel.