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. 2014 Oct 30;16(5):467. doi: 10.1186/s13075-014-0467-3

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© Kennedy et al.; licensee BioMed Central Ltd. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Observed versus population PK model predicted pateclizumab serum concentration-time profiles. Dose was given on study days 0, 14, 24, 42, 56, and 70. The empty symbols represent the observed individual serum concentrations at planned sampling times. The solid line represents the population PK model (built based on phase I PK data) predicted median serum concentration-time profile. The shaded band represents model predicted 90% confidence interval of the concentration-time profile for the study population. PK, pharmacokinetic.