Table 4.
Summary of associations of patient characteristics with risk of ESRD in multivariate Cox regression analysis
| Characteristic | Hazard Ratio (95% CI) | P Value |
|---|---|---|
| Prebaseline HbA1c (per 1–percentage point increase) | 1.72 (1.38 to 2.14) | <0.001 |
| HbA1c change (per 1–percentage point improvement) | 0.76 (0.63 to 0.91) | 0.003 |
| Male sex | 1.71 (1.04 to 2.82) | 0.03 |
| Duration of diabetes (per 10-yr increase) | 1.11 (0.80 to 1.54) | 0.52 |
| ACR (doubling) | 1.68 (1.33 to 2.12) | <0.001 |
| Baseline eGFR (per 10-ml/min per 1.73 m2 increase) | 0.71 (0.65 to 0.78) | <0.001 |
| Systolic BP (per 10-mmHg increase) | 0.97 (0.86 to 1.10) | 0.64 |
| Renoprotective treatment at baseline (yes) | 0.79 (0.48 to 1.31) | 0.36 |
| Calendar year of enrollment (per 1 yr later) | 0.97 (0.91 to 1.02) | 0.21 |
Similar estimates were obtained when the analysis was stratified by the median baseline eGFR (85 ml/min per 1.73 m2) and when stratified according to the presence at baseline of treatment with angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers (194 yes; 85 no).