Table 2.

Composition of antibiotic lock solutions used in the included studies of the meta-analysis

Study	Antibiotic Lock Solutions
Capdevila et al. 199320	Vancomycin or ciprofloxacin 100 μg/ml+5% sodium heparin. Both antibiotics with heparin were used in one patient.
Bailey et al. 200221	Vancomycin 100 μg/ml, gentamicin 20 μg/ml, or amphotericin B 2.5 mg/ml+heparin saline 5000 units/ml. Antibiotic combinations were not used.
Krishnasami et al. 200222	Vancomycin 2.5 mg/ml, gentamicin 1 mg/ml, cefazolin 5 mg/ml+heparin 2500 units/ml (gentamicin could be used alone or with heparin or another antibiotic could be added to the combination).
Vardhan et al. 200223	Vancomycin 100 μg/ml+gentamicin 20 μg/ml+heparin 5000 units/ml.
Poole et al. 200424	Vancomycin 2.5 mg/ml, ceftazidime 5 mg/ml, cefazolin 5 mg/ml+heparin 2500 units/ml. Each drug could be used alone with heparin or in combination.
Lee et al. 200514	Vancomycin 8.3 mg/ml, imipenem 32.3 mg/ml, ciprofloxacin 1.3 mg/ml, or ceftazidime 12.9 mg/ml+heparin 1774–4355 units/ml. Antibiotics were not combined.
Maya et al. 200725	Vancomycin 2.5 mg/ml or cefazolin 5 mg/ml+heparin 5000 units/ml.
Peterson et al. 200926	Vancomycin 2.5 mg/ml+heparin 5000 units/ml.
Onder et al. 2013,17 201027 (1/2004–6/2006)	Tobramycin 5 mg/ml or vancomycin 5 mg/ml+tissue plasminogen activator 1 mg/ml or heparin 5000 units/ml. Antibiotics were not combined.
Joshi and Hart 201228	Amikacin 25 mg/ml, amphotericin B 2.5 mg/ml, cefazolin 5 mg/ml, ceftazidime 5 mg/ml, gentamicin 1 mg/ml, or vancomycin 1 mg/ml+heparin 2500 units/ml. Gentamicin could also be combined with either vancomycin or cefazolin (in addition to heparin).

The concentrations cited are the final concentrations in the lock solutions.