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The absence of renal ACE blunts L-NAME–induced hypertension. The systolic BP (SBP) response to L-NAME (5 mg/10 ml in the drinking water) of ACE 10/10 (A), ACE 3/3 (B), and corresponding wild-type (WT) mice was determined by tail-cuff plethysmography. n=6–17. ***P<0.001 versus wild-type mice by two-way ANOVA. Values represent mean±SEM.
