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. 2014 May 22;25(12):2822–2834. doi: 10.1681/ASN.2013101102

Figure 6.

Figure 6.

AC6−/− mice reduce urinary phosphate and plasma PTH in response to a zero phosphate diet; however, they show greater increases in plasma phosphate after acute oral phosphate loading. (A) One week of zero phosphate intake (Zero Pi) significantly reduced urinary P/creatinine and plasma PTH levels in both genotypes (for comparison, values of the control diet [Con Pi] are shown from Figure 1). Plasma FGF-23 levels remained significantly higher in AC6−/−, whereas plasma phosphate was reduced to comparable levels in WT and AC6−/− mice. (B) Effects of acute oral phosphate loading. AC6−/− mice show a significantly greater increase in plasma phosphate after 30 and 60 minutes compared with WT mice. (C) Urinary phosphate/creatinine tended to be lower 60 minutes after phosphate loading in AC6−/− versus WT mice. For diets, n=9–11/genotype; for acute oral phosphate loading, n=4–8/group. *P<0.05 versus WT. #P<0.05 versus basal same genotype.