Figure 7.

Clearance experiments show higher fractional phosphate excretion and confirm the phosphate wasting phenotype of AC6^−/− mice. Higher fractional phosphate excretion in AC6^−/− mice. Acute bolus application of vehicle (0.85% NaCl) in clearance experiments under anesthesia resulted in comparable plasma phosphate levels between the genotypes, whereas AC6^−/− mice have a modestly lower GFR associated with a significantly higher fractional phosphate excretion. AC6^−/− mice have a significantly higher fractional fluid excretion. Although urinary cAMP excretion tended to be lower, it did not reach statistical significance (n=6–8/genotype). bw, body weight. *P<0.05 versus WT.